Innovative Methodology Stimulation pulse characteristics and electrode configuration determine site of excitation in isolated mammalian skeletal muscle: implications for fatigue
نویسندگان
چکیده
Simeon P. Cairns, Eva R. Chin, and Jean-Marc Renaud Institute of Sport and Recreation Research New Zealand, Faculty of Health and Environmental Science, Auckland University of Technology, and Department of Physiology, School of Medicine, University of Auckland, Auckland, New Zealand; Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, Connecticut; and Department of Cellular and Molecular Medicine, Neuromuscular Research Center, University of Ottawa, Ottawa, Ontario, Canada
منابع مشابه
Stimulation pulse characteristics and electrode configuration determine site of excitation in isolated mammalian skeletal muscle: implications for fatigue.
We examined whether electrical field stimulation with varying characteristics could excite isolated mammalian skeletal muscle through different sites. Supramaximal (20-V, 0.1-ms) pulse stimulation with transverse wire or parallel plate electrodes evoked similar forces in nonfatigued slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles from mice. d-tubocurarine shifted the ...
متن کاملChanges of surface and t-tubular membrane excitability during fatigue with repeated tetani in isolated mouse fast- and slow-twitch muscle.
We investigated whether impaired sarcolemmal excitability causes severe fatigue during repeated tetani in isolated mouse skeletal muscle. Slow-twitch soleus or fast-twitch extensor digitorum longus (EDL) muscles underwent intensive stimulation (standard protocol: 125 Hz for 500 ms, every second, parallel plate electrodes, 20 V, 0.1-ms pulses). Interventions with altered stimulation characterist...
متن کاملProtective role of extracellular chloride in fatigue of isolated mammalian skeletal muscle.
A possible role of extracellular Cl(-) concentration ([Cl(-)](o)) in fatigue was investigated in isolated skeletal muscles of the mouse. When [Cl(-)](o) was lowered from 128 to 10 mM, peak tetanic force was unchanged, fade was exacerbated (wire stimulation electrodes), and a hump appeared during tetanic relaxation in both nonfatigued slow-twitch soleus and fast-twitch extensor digitorum longus ...
متن کاملMatching initial torque with different stimulation parameters influences skeletal muscle fatigue.
A fundamental barrier to using electrical stimulation in the clinical setting is an inability to maintain torque production secondary to muscle fatigue. Electrical stimulation parameters are manipulated to influence muscle torque production, and they may also influence fatigability during repetitive stimulation. Our purpose was to determine the response of the quadriceps femoris to three differ...
متن کاملImpact of varying pulse frequency and duration on muscle torque production and fatigue.
Neuromuscular electrical stimulation (NMES) involves the use of electrical current to facilitate contraction of skeletal muscle. However, little is known concerning the effects of varying stimulation parameters on muscle function in humans. The purpose of this study was to determine the extent to which varying pulse duration and frequency altered torque production and fatigability of human skel...
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تاریخ انتشار 2007